CDCA4

Across TCGA cell cohorts, CDCA4 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDCA4-associated genes across cancer lineages are C14orf180, CLPSL1, and KRTAP10-2. Each is linked with CDCA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDCA4-to-partner and partner-to-CDCA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf180 grouped by CDCA4-low versus CDCA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDCA4→partner) and Y-score (partner→CDCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C14orf180 →	+0.102	+3.155	.002	.008	3	1
LARGE_INTESTINE	CLPSL1 →	+0.140	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.054	+3.994	<.001	.002	3	1
BLOOD_Leukemia	PHOX2B →	+0.021	+4.365	<.001	.002	3	1
BLOOD_Leukemia	IL2 →	+0.657	+3.691	<.001	.002	3	1
BLOOD_Leukemia	APOL5 →	+0.011	+3.475	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

C14orf180 by CDCA4 expression — LARGE_INTESTINE

Explore this box plot interactively →