CDCA4

Across TCGA pan-cancer cohorts, CDCA4 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CDCA4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CDCA4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDCA4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where CDCA4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDCA4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+2.014	<.001	12	view →
HNSC	Male	All	+1.757	<.001	12	view →
BLCA	Male	III,IV	+2.307	<.001	11	view →
KIRP	All	IV	+2.175	<.001	11	view →
LUAD	Male	III,IV	+1.545	<.001	11	view →
THCA	Male	III,IV	+0.754	<.001	10	view →
LIHC	Female	II,III,IV	+1.711	<.001	9	view →
STAD	Male	II,III,IV	+1.242	<.001	9	view →
KIRC	Male	All	+0.532	<.001	9	view →
LUSC	Male	II,III,IV	+2.485	<.001	8	view →
READ	All	All	+1.081	<.001	7	view →
UCEC	All	II,III,IV	+1.604	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CDCA4–COAD

Open the COAD breakdown →