CDC25B

Across TCGA cell cohorts, CDC25B mutation is significantly associated with the mutation status of many other genes, with 4,482 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC25B-associated genes across cancer lineages are SASH1, HNF1A, and CPAMD8. Each is linked with CDC25B in more than 3 cancer types. Because this analysis shows association rather than direction, both CDC25B-to-partner and partner-to-CDC25B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SASH1 grouped by CDC25B-low versus CDC25B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC25B→partner) and Y-score (partner→CDC25B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SASH1 →	+2.729	+3.643	<.001	<.001	1	4
LARGE_INTESTINE	HNF1A →	+2.630	+3.047	.005	.005	1	4
LARGE_INTESTINE	CPAMD8 →	+1.992	+3.963	.001	.001	1	4
STOMACH	TLN2 →	+3.357	+4.285	.005	.005	1	4
BLOOD_Lymphoma	EHD2 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	PLEKHH1 →	+5.584	+5.014	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,482 associations by consensus.

SASH1 by CDC25B expression — LARGE_INTESTINE

Explore this box plot interactively →