CDC25B

Across TCGA pan-cancer cohorts, CDC25B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CDC25B data layer compared with 7 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CDC25B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CDC25B expression acts as an unfavorable survival marker, although some lineages such as UCS and THYM show a favorable association.

UVM, ACC, and KIRC are the cancer types where CDC25B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.411	0.777	<.001	131	view →
ACC	DFS	Median	All	0.241	0.631	<.001	118	view →
KIRC	OS	Median	All	0.546	0.705	<.001	80	view →
LIHC	OS	Median	All	0.423	0.604	<.001	65	view →
LGG	DFS	Median	All	0.306	0.496	<.001	52	view →
UCS	DFS	Tertile	III,IV	0.629	0.183	.007	46	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	44	view →
UCEC	DFS	Median	All	0.791	0.884	.001	38	view →
BRCA	OS	Quartile	II,III,IV	0.860	0.947	<.001	37	view →
KIRP	OS	Quartile	All	0.568	0.821	.003	29	view →
SARC	OS	Median	All	0.655	0.870	<.001	28	view →
LAML	DFS	Tertile	All	0.352	0.780	<.001	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CDC25B–UVM (OS)

Open the UVM breakdown →