Q-omics provides the consensus-scored CD27-AS1 profile across patient tissues and cancer cell-line models. CD27-AS1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, CD27-AS1 is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, CD27-AS1 RNA expression shows 19,570 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, and UVM as cancer lineages where CD27-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CD27-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CD27-AS1 survival associations across molecular data types. CD27-AS1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CD27-AS1 RNA expression–survival associations across cancer types. High CD27-AS1 expression shows unfavorable associations in KIRC, UVM, COAD, LIHC and KICH, but favorable associations in SKCM. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for CD27-AS1 RNA expression.
This table summarizes CD27-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for CD27-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CD27-AS1 shows lower tumor expression in UCEC and higher tumor expression in KIRC, KIRP, LIHC, HNSC and CHOL. The KIRC box plot shows higher CD27-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.751, t-test p < 0.001).
This table shows molecular features associated with CD27-AS1 in patient tissues and cancer cell lines. In patient samples, CD27-AS1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
