CCNO

Across TCGA cell cohorts, CCNO mutation is significantly associated with the mutation status of many other genes, with 1,007 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCNO-associated genes across cancer lineages are WDR24, ABL1, and GBF1. Each is linked with CCNO in more than 2 cancer types. Because this analysis shows association rather than direction, both CCNO-to-partner and partner-to-CCNO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR24 grouped by CCNO-low versus CCNO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNO→partner) and Y-score (partner→CCNO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR24 →	+2.865	+4.217	.007	.007	1	3
OVARY	ABL1 →	+4.415	+4.977	.007	.007	1	3
OVARY	GBF1 →	+5.415	+5.415	.004	.004	1	3
LUNG_NSCLC_LUAD	SASH1 →	+5.303	+4.339	<.001	<.001	1	3
LARGE_INTESTINE	CAPN15 →	+2.865	+4.217	.007	.007	1	2
LARGE_INTESTINE	IGDCC4 →	+2.865	+4.217	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,007 associations by consensus.

WDR24 by CCNO expression — LARGE_INTESTINE

Explore this box plot interactively →