CCDC170

Across TCGA cell cohorts, CCDC170 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCDC170-associated genes across cancer lineages are CTXN3, SLC35G3, and OR5B12. Each is linked with CCDC170 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC170-to-partner and partner-to-CCDC170 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTXN3 grouped by CCDC170-low versus CCDC170-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC170→partner) and Y-score (partner→CCDC170) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CTXN3 →	+0.041	+4.212	<.001	.007	3	2
BLOOD_Leukemia	SLC35G3 →	+0.036	+3.704	<.001	.001	3	1
BLOOD_Leukemia	OR5B12 →	+0.028	+4.189	.002	<.001	3	1
BLOOD_Leukemia	TAS1R2 →	+0.010	+3.177	<.001	.004	3	1
BLOOD_Leukemia	HEPN1 →	+0.722	+3.007	<.001	.007	3	1
BLOOD_Leukemia	IQCA1L →	+0.144	+2.974	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CTXN3 by CCDC170 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →