CCDC170

Across TCGA pan-cancer cohorts, CCDC170 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CCDC170’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCDC170 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC170 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where CCDC170 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC170 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.587	<.001	11	view →
KICH	Female	II,III,IV	−1.450	<.001	10	view →
LUAD	All	III,IV	−1.485	<.001	9	view →
LUSC	Female	All	−2.435	<.001	8	view →
LIHC	Male	All	+1.488	<.001	8	view →
COAD	Male	II,III,IV	+1.060	<.001	5	view →
BLCA	Male	All	−0.554	.008	4	view →
ESCA	All	II,III,IV	+1.115	.021	2	view →
KIRC	All	All	−0.174	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CCDC170–THCA

Open the THCA breakdown →