CBX6

Across TCGA cell cohorts, CBX6 mutation is significantly associated with the RNA expression of many other genes, with 161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBX6-associated genes across cancer lineages are AVP, CRISP1, and C22orf42. Each is linked with CBX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX6-to-partner and partner-to-CBX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by CBX6-low versus CBX6-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX6→partner) and Y-score (partner→CBX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AVP →	+0.097	+4.977	<.001	.002	3	1
SOFT_TISSUE	CRISP1 →	+0.036	+4.882	.004	.001	3	1
SOFT_TISSUE	C22orf42 →	+0.094	+4.222	<.001	.007	3	1
SOFT_TISSUE	OR7E24 →	+0.022	+4.369	<.001	.008	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	GPR142 →	+0.037	+4.882	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 161 associations by consensus.

AVP by CBX6 expression — SOFT_TISSUE

Explore this box plot interactively →