CBX6

Across TCGA pan-cancer cohorts, CBX6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CBX6’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CBX6 RNA is repressed in tumor relative to normal tissue. In most cancer types CBX6 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and UCEC are the cancer types where CBX6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CBX6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−2.300	<.001	8	view →
KICH	All	All	−1.069	<.001	8	view →
UCEC	All	All	−2.056	<.001	6	view →
LIHC	All	II,III,IV	+1.209	<.001	6	view →
LUAD	All	II,III,IV	−0.745	<.001	6	view →
BRCA	All	II,III,IV	−0.728	<.001	6	view →
COAD	All	All	−0.727	<.001	6	view →
KIRC	Male	II,III,IV	−0.588	<.001	6	view →
HNSC	Male	III,IV	+0.840	.012	5	view →
CHOL	Female	All	+3.023	<.001	3	view →
PRAD	All	All	−0.445	.001	2	view →
READ	All	All	−1.148	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CBX6–BLCA

Open the BLCA breakdown →