CBX6

Across TCGA pan-cancer cohorts, CBX6 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CBX6 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher CBX6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CBX6 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LGG show a favorable association.

PAAD, ACC, and LGG are the cancer types where CBX6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Median	All	0.595	0.383	<.001	71	view →
ACC	DFS	Median	All	0.241	0.633	<.001	62	view →
LGG	OS	Median	All	0.936	0.850	<.001	45	view →
KIRC	DFS	Tertile	All	0.818	0.513	<.001	28	view →
SCLC	OS	Tertile	All	0.728	0.448	.005	25	view →
BLCA	DFS	Median	II,III,IV	0.278	0.408	.011	21	view →
ESCA	OS	Quartile	II,III,IV	0.845	0.559	.003	19	view →
UCEC	OS	Quartile	All	0.862	0.959	<.001	18	view →
LIHC	OS	Median	All	0.728	0.823	.006	12	view →
KIRP	DFS	Median	All	0.981	0.771	.001	12	view →
PCPG	DFS	Median	All	0.946	0.825	.013	12	view →
COAD	DFS	Median	All	0.627	0.742	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CBX6–PAAD (OS)

Open the PAAD breakdown →