CBX4

Across TCGA patient cohorts, CBX4 mutation is significantly associated with the RNA expression of many other genes, with 1,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX4-associated genes across cancer lineages are MIR6075, SAGE3P, and FAM27B. Each is linked with CBX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX4-to-partner and partner-to-CBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6075 grouped by CBX4-low versus CBX4-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX4→partner) and Y-score (partner→CBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR6075 →	+0.445	+5.544	<.001	.004	3	2
CESC	SAGE3P →	+0.025	+6.569	<.001	.001	3	2
BLCA	FAM27B →	+0.115	+4.618	<.001	.005	3	2
UCEC	RNA5SP411 →	+0.853	+2.104	.002	.001	3	2
LIHC	RN7SL89P →	+0.177	+6.149	<.001	.002	3	2
LIHC	LINC02353 →	+0.092	+5.355	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,109 associations by consensus.

MIR6075 by CBX4 expression — LIHC

Explore this box plot interactively →