CBX4

Across TCGA pan-cancer cohorts, CBX4 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated CBX4 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CBX4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CBX4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

KIRC, KIRP, and ACC are the cancer types where CBX4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.499	0.755	<.001	118	view →
KIRP	OS	Median	All	0.818	0.935	.001	89	view →
ACC	OS	Median	All	0.428	0.805	<.001	86	view →
KICH	OS	Median	III,IV	0.468	1.000	.001	56	view →
LIHC	OS	Tertile	All	0.595	0.782	<.001	36	view →
SKCM	DFS	Median	IV	0.187	0.763	.006	21	view →
ESCA	DFS	Tertile	II,III,IV	0.302	0.557	.001	20	view →
HNSC	DFS	Median	IV	0.443	0.237	.001	17	view →
COAD	DFS	Median	II,III,IV	0.383	0.580	.001	17	view →
LUSC	DFS	Quartile	III,IV	0.532	0.841	.009	15	view →
STAD	OS	Median	IV	0.564	0.192	.004	11	view →
BRCA	OS	Quartile	III,IV	0.957	0.841	.008	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

CBX4–KIRC (DFS)

Open the KIRC breakdown →