CARD18

Across TCGA patient cohorts, CARD18 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CARD18-associated genes across cancer lineages are CTBP2P10, IL21, and MIR133B. Each is linked with CARD18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CARD18-to-partner and partner-to-CARD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTBP2P10 grouped by CARD18-low versus CARD18-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD18→partner) and Y-score (partner→CARD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CTBP2P10 →	+0.029	+4.393	<.001	.008	3	2
UCEC	IL21 →	+0.223	+2.763	<.001	.009	3	1
SKCM	MIR133B →	+1.050	+5.993	<.001	.001	3	1
SKCM	RNU4-58P →	+0.334	+4.970	<.001	.005	3	1
SKCM	RPS6P2 →	+0.100	+5.163	<.001	.001	3	1
UCEC	URGCP-MRPS24 →	+0.272	+3.421	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

CTBP2P10 by CARD18 expression — LUSC

Explore this box plot interactively →