CARD18

Across TCGA pan-cancer cohorts, CARD18 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated CARD18 data layer compared with 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CARD18 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CARD18 expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.

UCEC, READ, and SKCM are the cancer types where CARD18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.520	0.690	<.001	84	view →
READ	OS	Tertile	II,III,IV	0.111	0.919	<.001	63	view →
SKCM	OS	Tertile	All	0.658	0.812	<.001	62	view →
BRCA	OS	Quartile	III,IV	0.825	0.926	.005	59	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	51	view →
UCS	OS	Quartile	All	0.814	0.556	.009	46	view →
SARC	OS	Tertile	All	0.533	0.770	<.001	30	view →
LGG	OS	Median	All	0.951	0.862	<.001	24	view →
KIRC	DFS	Tertile	IV	1.000	0.399	.041	18	view →
LIHC	OS	Quartile	All	0.661	0.809	.011	14	view →
STAD	DFS	Median	All	0.631	0.783	.024	10	view →
MESO	OS	Tertile	IV	0.155	0.624	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

CARD18–UCEC (DFS)

Open the UCEC breakdown →