C8orf44-SGK3

Across TCGA patient cohorts, C8orf44-SGK3 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible C8orf44-SGK3-associated genes across cancer lineages are RNA5SP291, TXNP2, and OR5K4. Each is linked with C8orf44-SGK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf44-SGK3-to-partner and partner-to-C8orf44-SGK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP291 grouped by C8orf44-SGK3-low versus C8orf44-SGK3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf44-SGK3→partner) and Y-score (partner→C8orf44-SGK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP291 →	+0.552	+7.930	<.001	.008	3	2
LUSC	TXNP2 →	+0.121	+4.792	<.001	.006	3	2
SKCM	OR5K4 →	+0.039	+7.816	<.001	.008	3	1
BLCA	COX6CP16 →	+0.244	+5.177	<.001	.007	3	1
BLCA	LINC00226 →	+0.409	+4.973	<.001	.009	3	1
BLCA	MIR6892 →	+0.387	+7.632	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RNA5SP291 by C8orf44-SGK3 expression — LUAD

Explore this box plot interactively →