long intergenic non-protein coding RNA 226Genealiases: C14orf97 · NCRNA00226
Q-omics provides the consensus-scored LINC00226 profile across patient tissues and cancer cell-line models. LINC00226 expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, LINC00226 is differentially expressed in 3, with the highest sampling consensus in KIRC. Additionally, LINC00226 RNA expression shows 11,677 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight BRCA, KIRC, and THYM as cancer lineages where LINC00226 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00226 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00226 survival associations across molecular data types. LINC00226 RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00226 RNA expression–survival associations across cancer types. High LINC00226 expression shows unfavorable associations in BRCA, BLCA, STAD and KICH, but favorable associations in UCS and LUAD. The BRCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify BRCA as the clearest survival context for LINC00226 RNA expression.
This table summarizes LINC00226 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00226. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00226 shows lower tumor expression in COAD and higher tumor expression in KIRC and BRCA. The KIRC box plot shows higher LINC00226 RNA expression in tumor versus normal tissue (log2 FC = +0.032, t-test p = .001).
This table shows molecular features associated with LINC00226 in patient tissues and cancer cell lines. In patient samples, LINC00226 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
