C8orf44-SGK3

Across TCGA pan-cancer cohorts, C8orf44-SGK3 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated C8orf44-SGK3 data layer compared with 3 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher C8orf44-SGK3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C8orf44-SGK3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

SKCM, UCS, and UVM are the cancer types where C8orf44-SGK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Quartile	All	0.285	0.142	.005	44	view →
UCS	OS	Quartile	II,III,IV	0.668	0.153	.002	38	view →
UVM	DFS	Median	III,IV	0.272	0.704	.006	33	view →
THYM	DFS	Quartile	II,III,IV	0.951	0.507	.005	31	view →
COAD	OS	Tertile	All	0.498	0.785	.001	25	view →
BRCA	DFS	Tertile	III,IV	0.937	0.778	.001	23	view →
KICH	OS	Quartile	II,III,IV	0.548	0.927	.017	21	view →
SCLC	OS	Median	All	0.479	0.665	.015	21	view →
THCA	DFS	Quartile	III,IV	0.796	0.930	.007	20	view →
READ	DFS	Tertile	IV	0.266	0.771	.001	19	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
MESO	OS	Median	II,III,IV	0.695	0.351	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

C8orf44-SGK3–SKCM (DFS)

Open the SKCM breakdown →