C8orf44-SGK3

Across TCGA pan-cancer cohorts, C8orf44-SGK3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of C8orf44-SGK3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C8orf44-SGK3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C8orf44-SGK3 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where C8orf44-SGK3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C8orf44-SGK3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.076	<.001	11	view →
KICH	All	III,IV	−0.091	.005	6	view →
LIHC	Male	All	+0.070	<.001	6	view →
STAD	Male	II,III,IV	+0.123	.026	2	view →
UCEC	All	All	−0.083	<.001	2	view →
KIRC	Female	III,IV	+0.056	.026	2	view →
THCA	All	All	−0.043	.007	2	view →
CHOL	All	All	+0.040	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

C8orf44-SGK3–HNSC

Open the HNSC breakdown →