C8B

Across TCGA cell cohorts, C8B mutation is significantly associated with the mutation status of many other genes, with 4,013 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C8B-associated genes across cancer lineages are ADAMTS18, BRINP3, and PPP1R13B. Each is linked with C8B in more than 3 cancer types. Because this analysis shows association rather than direction, both C8B-to-partner and partner-to-C8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTS18 grouped by C8B-low versus C8B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8B→partner) and Y-score (partner→C8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ADAMTS18 →	+4.562	+5.217	<.001	<.001	1	4
LARGE_INTESTINE	BRINP3 →	+2.807	+2.954	.001	.001	1	4
BONE	PPP1R13B →	+5.000	+4.437	.007	.007	1	3
BREAST	UNC5D →	+5.297	+5.297	.004	.004	1	3
SOFT_TISSUE	UNC5C →	+4.502	+5.066	.007	.007	1	3
BREAST	MARK3 →	+5.297	+5.297	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,013 associations by consensus.

ADAMTS18 by C8B expression — OVARY

Explore this box plot interactively →