C8B

Across TCGA pan-cancer cohorts, C8B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated C8B data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher C8B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C8B expression acts as an unfavorable survival marker, although some lineages such as LIHC and LUAD show a favorable association.

STAD, LIHC, and UCS are the cancer types where C8B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	III,IV	0.283	0.662	.005	58	view →
LIHC	OS	Median	All	0.575	0.433	<.001	55	view →
UCS	OS	Quartile	III,IV	0.137	0.568	.007	48	view →
KICH	OS	Quartile	II,III,IV	0.308	0.882	.001	47	view →
LUSC	OS	Quartile	All	0.299	0.535	<.001	42	view →
HNSC	OS	Quartile	II,III,IV	0.397	0.641	.014	24	view →
LUAD	OS	Tertile	All	0.520	0.246	.002	21	view →
KIRP	OS	Tertile	All	0.454	0.745	.008	19	view →
LGG	DFS	Quartile	All	0.580	0.763	<.001	17	view →
BRCA	OS	Median	III,IV	0.864	0.940	.021	13	view →
ESCA	OS	Tertile	IV	0.195	0.718	.038	12	view →
PAAD	DFS	Median	II,III,IV	0.352	0.517	.028	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

C8B–STAD (OS)

Open the STAD breakdown →