Q-omics provides the consensus-scored C5orf64 profile across patient tissues and cancer cell-line models. C5orf64 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, C5orf64 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, C5orf64 RNA expression shows 14,542 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight BRCA, THCA, and UVM as cancer lineages where C5orf64 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C5orf64 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C5orf64 survival associations across molecular data types. C5orf64 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C5orf64 RNA expression–survival associations across cancer types. High C5orf64 expression shows unfavorable associations in KIRP and LIHC, but favorable associations in BRCA, LUAD, KIRC and SCLC. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .005). Together, the overview and detailed table identify BRCA as the clearest survival context for C5orf64 RNA expression.
This table summarizes C5orf64 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for C5orf64. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C5orf64 shows lower tumor expression in THCA, LUAD, LUSC, COAD and BRCA and higher tumor expression in KICH. The THCA box plot shows higher C5orf64 RNA expression in normal versus tumor tissue (log2 FC = −0.201, t-test p < 0.001).
This table shows molecular features associated with C5orf64 in patient tissues and cancer cell lines. In patient samples, C5orf64 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, C5orf64 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE.
