Q-omics provides the consensus-scored C5orf58 profile across patient tissues and cancer cell-line models. C5orf58 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, C5orf58 is differentially expressed in 9, with the highest sampling consensus in KIRC. Additionally, C5orf58 RNA expression shows 17,745 significant gene co-expression associations, with the highest sampling consensus in DLBC. Together, these results highlight UVM, KIRC, and DLBC as cancer lineages where C5orf58 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C5orf58 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C5orf58 survival associations across molecular data types. C5orf58 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C5orf58 RNA expression–survival associations across cancer types. High C5orf58 expression shows unfavorable associations in UVM and STAD, but favorable associations in SKCM, LUAD, HNSC and CESC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for C5orf58 RNA expression.
This table summarizes C5orf58 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for C5orf58. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C5orf58 shows higher tumor expression in KIRC, STAD, LIHC, HNSC, LUAD and KIRP. The KIRC box plot shows higher C5orf58 RNA expression in tumor versus normal tissue (log2 FC = +0.282, t-test p < 0.001).
This table shows molecular features associated with C5orf58 in patient tissues and cancer cell lines. In patient samples, C5orf58 shows the broadest associations at the RNA and protein expression levels, with DLBC recurring as the lineage with the largest associated feature set. In cancer cell lines, C5orf58 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia.
