C5orf58

Across TCGA patient cohorts, C5orf58 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C5orf58-associated genes across cancer lineages are RN7SKP181, CDKN2AIPNLP3, and KRTAP8-2P. Each is linked with C5orf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf58-to-partner and partner-to-C5orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by C5orf58-low versus C5orf58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf58→partner) and Y-score (partner→C5orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.423	+5.133	<.001	.008	3	1
UCEC	CDKN2AIPNLP3 →	+0.273	+5.852	<.001	.003	3	1
UCEC	KRTAP8-2P →	+0.516	+5.937	<.001	.002	3	1
UCEC	TEMN3-AS1 →	+1.062	+5.551	<.001	.004	3	1
SKCM	MIR3679 →	+0.511	+5.436	<.001	.005	3	1
SKCM	SDHDP1 →	+0.094	+5.292	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

RN7SKP181 by C5orf58 expression — UCEC

Explore this box plot interactively →