C5orf58

Across TCGA cell cohorts, C5orf58 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,029 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C5orf58-associated GO terms across cancer lineages are Negative regulation of calcium ion import across plasma membrane, Positive regulation of epidermis development, and Trabecula formation. Each is linked with C5orf58 in more than 3 cancer types. Because this analysis shows association rather than direction, both C5orf58-to-partner and partner-to-C5orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion import across plasma membrane grouped by C5orf58-low versus C5orf58-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf58→partner) and Y-score (partner→C5orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of calcium ion import across plasma membrane →	-0.057	-0.328	.006	.002	3	4
BLOOD_Leukemia	Positive regulation of epidermis development →	-0.036	-0.253	.007	.008	3	4
BLOOD_Lymphoma	Trabecula formation →	-0.270	-0.288	<.001	<.001	3	3
BLOOD_Lymphoma	Heart trabecula formation →	-0.272	-0.289	<.001	<.001	3	3
SKIN	Negative regulation of B cell proliferation →	-0.211	-0.568	<.001	.006	3	3
BLOOD_Leukemia	Negative regulation of lymphocyte apoptotic process →	-0.069	-0.340	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,029 associations by consensus.

Negative regulation of calcium ion import across plasma membrane by C5orf58 expression — BLOOD_Leukemia

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