C4orf50

Across TCGA patient cohorts, C4orf50 mutation is significantly associated with the RNA expression of many other genes, with 1,137 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C4orf50-associated genes across cancer lineages are RN7SL250P, RPL5P32, and PLEKHM1. Each is linked with C4orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf50-to-partner and partner-to-C4orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL250P grouped by C4orf50-low versus C4orf50-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf50→partner) and Y-score (partner→C4orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL250P →	+0.088	+3.040	<.001	.002	3	2
LUAD	RPL5P32 →	+0.186	+3.577	<.001	.004	3	2
UCEC	PLEKHM1 →	+0.467	+2.595	.003	.006	3	2
UCEC	LCT-AS1 →	+0.149	+2.681	.002	.005	3	2
UCEC	RNU6-120P →	+0.289	+3.249	<.001	.005	3	2
SKCM	BPGM →	+0.491	+2.655	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,137 associations by consensus.

RN7SL250P by C4orf50 expression — SKCM

Explore this box plot interactively →