C4orf50

Across TCGA pan-cancer cohorts, C4orf50 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C4orf50 data layer compared with 7 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher C4orf50 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C4orf50 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and ACC are the cancer types where C4orf50 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.435	0.268	<.001	106	view →
HNSC	DFS	Tertile	III,IV	0.729	0.511	<.001	79	view →
ACC	OS	Tertile	All	0.368	0.876	<.001	76	view →
KIRP	DFS	Tertile	All	0.754	0.937	<.001	39	view →
SARC	OS	Tertile	All	0.905	0.745	<.001	27	view →
MESO	OS	Median	II,III,IV	0.662	0.468	.003	26	view →
STAD	DFS	Tertile	IV	1.000	0.259	.005	26	view →
PAAD	DFS	Quartile	All	0.352	0.163	.006	22	view →
CESC	DFS	Median	All	0.800	0.679	.009	14	view →
UVM	OS	Tertile	All	0.397	0.746	.032	14	view →
BRCA	DFS	Tertile	All	0.924	0.956	.012	13	view →
THYM	DFS	Quartile	II,III,IV	0.657	1.000	.024	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C4orf50–SKCM (OS)

Open the SKCM breakdown →