C4orf50

Across TCGA pan-cancer cohorts, C4orf50 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C4orf50’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C4orf50 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C4orf50 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where C4orf50 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C4orf50 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.080	<.001	10	view →
THCA	All	All	−0.077	<.001	8	view →
HNSC	All	All	+0.041	.001	8	view →
KICH	All	All	−0.016	<.001	6	view →
BRCA	Female	II,III,IV	+0.104	<.001	4	view →
LIHC	Female	III,IV	+0.018	.001	4	view →
LUAD	All	All	+0.093	<.001	3	view →
KIRP	Male	II,III,IV	+0.090	.020	3	view →
COAD	Female	All	−0.046	.016	3	view →
PRAD	All	All	−0.077	.023	2	view →
BLCA	Male	III,IV	+0.044	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

C4orf50–KIRC

Open the KIRC breakdown →