C2orf74

Across TCGA patient cohorts, C2orf74 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2orf74-associated genes across cancer lineages are MINAR2, PPP3R2, and BLOC1S6P1. Each is linked with C2orf74 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf74-to-partner and partner-to-C2orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MINAR2 grouped by C2orf74-low versus C2orf74-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf74→partner) and Y-score (partner→C2orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MINAR2 →	+0.258	+3.326	.001	.009	3	1
UCEC	PPP3R2 →	+0.089	+2.863	<.001	.004	3	1
UCEC	BLOC1S6P1 →	+0.224	+2.577	.001	.009	3	1
UCEC	LINC00477 →	+0.182	+4.028	.003	<.001	3	1
UCEC	RNA5SP516 →	+0.387	+3.937	<.001	.001	3	1
UCEC	OR6C72P →	+0.082	+4.027	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

MINAR2 by C2orf74 expression — UCEC

Explore this box plot interactively →