C2orf74

Across TCGA pan-cancer cohorts, C2orf74 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of C2orf74’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C2orf74 RNA is repressed in tumor relative to normal tissue. In most cancer types C2orf74 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where C2orf74 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2orf74 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.861	<.001	12	view →
KICH	Female	All	−1.592	<.001	11	view →
BLCA	All	All	−1.012	<.001	9	view →
THCA	All	All	−0.361	<.001	8	view →
UCEC	All	II,III,IV	−2.456	<.001	6	view →
BRCA	All	III,IV	−0.874	<.001	6	view →
LUSC	All	All	−0.715	<.001	5	view →
HNSC	Female	All	+0.660	.004	4	view →
KIRP	All	All	−0.479	.002	4	view →
STAD	All	All	−0.540	.012	3	view →
LIHC	All	All	+0.336	.001	3	view →
READ	Female	All	−1.573	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

C2orf74–COAD

Open the COAD breakdown →