C2orf74

Across TCGA pan-cancer cohorts, C2orf74 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated C2orf74 data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher C2orf74 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C2orf74 expression acts as an unfavorable survival marker, although some lineages such as MESO and SARC show a favorable association.

MESO, KICH, and SARC are the cancer types where C2orf74 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.495	0.273	<.001	90	view →
KICH	OS	Median	II,III,IV	0.869	1.000	.002	53	view →
SARC	OS	Median	All	0.676	0.342	<.001	30	view →
UVM	DFS	Median	III,IV	0.286	0.751	.011	28	view →
OV	OS	Median	III,IV	0.736	0.627	.002	24	view →
BRCA	DFS	Tertile	IV	0.316	0.797	.005	24	view →
SCLC	OS	Tertile	IV	0.201	0.653	.006	24	view →
KIRP	DFS	Quartile	II,III,IV	1.000	0.286	.013	22	view →
HNSC	OS	Tertile	All	0.292	0.550	.014	13	view →
CESC	OS	Median	IV	0.813	0.357	.010	12	view →
KIRC	DFS	Median	IV	0.621	0.272	.001	12	view →
COAD	DFS	Median	IV	0.369	0.591	.026	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

C2orf74–MESO (OS)

Open the MESO breakdown →