C22orf31

Across TCGA patient cohorts, C22orf31 mutation is significantly associated with the RNA expression of many other genes, with 1,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C22orf31-associated genes across cancer lineages are RNU6-709P, CCL27, and RNU6-728P. Each is linked with C22orf31 in more than 1 cancer types. Because this analysis shows association rather than direction, both C22orf31-to-partner and partner-to-C22orf31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by C22orf31-low versus C22orf31-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf31→partner) and Y-score (partner→C22orf31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-709P →	+0.450	+8.174	<.001	<.001	3	2
CESC	CCL27 →	+0.087	+5.812	<.001	.003	3	2
UCEC	RNU6-728P →	+0.118	+2.920	.002	.008	3	2
UCEC	RNA5SP419 →	+0.451	+1.961	.004	.009	3	2
BLCA	MIR4305 →	+0.342	+5.177	.005	.007	3	1
BLCA	MIR5580 →	+0.715	+5.106	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,015 associations by consensus.

RNU6-709P by C22orf31 expression — CESC

Explore this box plot interactively →