Across TCGA patient cohorts, C1orf53 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf53-associated genes across cancer lineages are MIR4538, RN7SL744P, and MIR6783. Each is linked with C1orf53 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf53-to-partner and partner-to-C1orf53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf53→partner) and Y-score (partner→C1orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4538 →	+1.203	+3.191	<.001	.003	3	1
UCEC	RN7SL744P →	+0.330	+3.050	.003	.005	3	1
UCEC	MIR6783 →	+0.808	+3.254	<.001	.002	3	1
SKCM	RNU6-643P →	+0.312	+7.816	<.001	.008	3	1
SKCM	RNU6-456P →	+0.313	+7.816	<.001	.008	3	1
SKCM	MIR544A →	+0.357	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

C1orf53 survival (RNA) · tumor vs normal (RNA) · all C1orf53 data types