Q-omics provides the consensus-scored MIR4538 profile across patient tissues and cancer cell-line models. MIR4538 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, MIR4538 is differentially expressed in 6, with the highest sampling consensus in COAD. Additionally, MIR4538 RNA expression shows 13,364 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight HNSC, COAD, and UVM as cancer lineages where MIR4538 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR4538 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR4538 survival associations across molecular data types. MIR4538 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR4538 RNA expression–survival associations across cancer types. High MIR4538 expression shows unfavorable associations in UVM and GBM, but favorable associations in HNSC, SKCM, OV and LUAD. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for MIR4538 RNA expression.
This table summarizes MIR4538 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR4538. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR4538 shows lower tumor expression in COAD and THCA and higher tumor expression in HNSC, KIRC, LUAD and STAD. The COAD box plot shows higher MIR4538 RNA expression in normal versus tumor tissue (log2 FC = −0.867, t-test p = .002).
This table shows molecular features associated with MIR4538 in patient tissues and cancer cell lines. In patient samples, MIR4538 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
