MIR4538

Across TCGA pan-cancer cohorts, MIR4538 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MIR4538 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MIR4538 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MIR4538 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where MIR4538 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.740	0.606	<.001	144	view →
SKCM	DFS	Median	All	0.683	0.548	<.001	117	view →
UVM	DFS	Tertile	All	0.261	0.672	<.001	72	view →
OV	DFS	Tertile	All	0.448	0.352	.012	52	view →
LUAD	OS	Quartile	All	0.780	0.601	<.001	43	view →
GBM	OS	Tertile	All	0.041	0.423	<.001	36	view →
CHOL	DFS	Tertile	All	0.750	0.254	.007	24	view →
ESCA	DFS	Quartile	II,III,IV	0.687	0.422	.005	24	view →
THCA	OS	Tertile	All	1.000	0.985	.024	22	view →
DLBC	OS	Median	All	1.000	0.396	.017	13	view →
STAD	DFS	Median	II,III,IV	0.645	0.367	.013	12	view →
LIHC	DFS	Tertile	All	0.691	0.521	.026	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MIR4538–HNSC (OS)

Open the HNSC breakdown →