MIR4538

Across TCGA pan-cancer cohorts, MIR4538 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MIR4538’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MIR4538 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR4538 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, HNSC, and KIRC are the cancer types where MIR4538 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR4538 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.867	.002	7	view →
HNSC	Female	II,III,IV	+0.854	.002	7	view →
KIRC	All	All	+0.387	<.001	5	view →
LUAD	All	All	+0.828	<.001	4	view →
STAD	Female	All	+1.551	.048	2	view →
THCA	All	All	−0.486	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MIR4538–COAD

Open the COAD breakdown →