C1S

Across TCGA patient cohorts, C1S mutation is significantly associated with the RNA expression of many other genes, with 2,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1S-associated genes across cancer lineages are MIR6780A, CIDECP1, and ALMS1-IT1. Each is linked with C1S in more than 2 cancer types. Because this analysis shows association rather than direction, both C1S-to-partner and partner-to-C1S results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780A grouped by C1S-low versus C1S-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1S→partner) and Y-score (partner→C1S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR6780A →	+0.503	+3.971	<.001	.005	3	3
SKCM	CIDECP1 →	+0.393	+2.121	<.001	<.001	3	3
UCEC	ALMS1-IT1 →	+0.355	+2.191	<.001	.001	3	3
UCEC	PELO →	+0.438	+1.711	<.001	.001	3	2
UCEC	ZUP1 →	+0.442	+2.706	<.001	<.001	3	2
UCEC	BUB3 →	+0.401	+2.162	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,213 associations by consensus.

MIR6780A by C1S expression — BLCA

Explore this box plot interactively →