C1S

Across TCGA pan-cancer cohorts, C1S RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C1S data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher C1S RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C1S expression acts as an unfavorable survival marker, although some lineages such as LIHC and SKCM show a favorable association.

KIRC, LIHC, and SKCM are the cancer types where C1S RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.543	0.717	<.001	84	view →
LIHC	OS	Quartile	II,III,IV	0.817	0.461	.003	83	view →
SKCM	OS	Quartile	All	0.470	0.262	<.001	69	view →
KIRP	DFS	Tertile	All	0.845	0.966	<.001	68	view →
LGG	OS	Median	All	0.736	0.880	<.001	54	view →
UVM	DFS	Median	All	0.338	0.566	.012	42	view →
MESO	OS	Quartile	All	0.653	0.346	.001	28	view →
HNSC	DFS	Median	IV	0.653	0.495	.006	28	view →
SARC	OS	Median	All	0.832	0.658	<.001	25	view →
GBM	DFS	Tertile	All	0.210	0.425	.011	24	view →
ACC	OS	Median	IV	0.309	0.777	.019	18	view →
ESCA	DFS	Tertile	III,IV	0.583	0.263	.004	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C1S–KIRC (OS)

Open the KIRC breakdown →