C1S

Across TCGA pan-cancer cohorts, C1S RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of C1S’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where C1S RNA is repressed in tumor relative to normal tissue. In most cancer types C1S is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, HNSC, and THCA are the cancer types where C1S tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1S RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−4.215	<.001	10	view →
HNSC	Female	III,IV	+2.300	<.001	10	view →
THCA	Female	II,III,IV	−2.567	<.001	9	view →
KIRC	Male	All	+1.408	<.001	9	view →
BLCA	Male	All	−2.432	<.001	8	view →
LIHC	Female	All	−1.317	<.001	7	view →
UCEC	All	All	−2.765	<.001	6	view →
BRCA	All	II,III,IV	−0.757	<.001	6	view →
CHOL	All	All	−2.246	<.001	4	view →
KIRP	All	II,III,IV	+1.059	.036	4	view →
STAD	Male	II,III,IV	+1.036	.023	2	view →
LUSC	Female	III,IV	+1.170	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

C1S–KICH

Open the KICH breakdown →