C17orf49

Across TCGA patient cohorts, C17orf49 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C17orf49-associated genes across cancer lineages are HIGD1AP2, ATF4P1, and MTND5P16. Each is linked with C17orf49 in more than 1 cancer types. Because this analysis shows association rather than direction, both C17orf49-to-partner and partner-to-C17orf49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1AP2 grouped by C17orf49-low versus C17orf49-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C17orf49→partner) and Y-score (partner→C17orf49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HIGD1AP2 →	+0.224	+6.797	<.001	<.001	3	2
UCEC	ATF4P1 →	+0.111	+3.395	<.001	.002	3	2
SKCM	MTND5P16 →	+0.077	+4.979	<.001	.009	3	1
SKCM	RNA5SP384 →	+0.550	+5.867	<.001	.003	3	1
SKCM	CACNA1C-IT3 →	+0.070	+4.979	.004	.009	3	1
SKCM	LINC02622 →	+0.052	+5.680	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

HIGD1AP2 by C17orf49 expression — SKCM

Explore this box plot interactively →