C12orf75

Across TCGA patient cohorts, C12orf75 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf75-associated genes across cancer lineages are LARP7P1, SNORD114-7, and RNA5SP389. Each is linked with C12orf75 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf75-to-partner and partner-to-C12orf75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP7P1 grouped by C12orf75-low versus C12orf75-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf75→partner) and Y-score (partner→C12orf75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LARP7P1 →	+0.283	+5.186	<.001	.007	3	1
UCEC	SNORD114-7 →	+0.851	+6.877	<.001	<.001	3	1
UCEC	RNA5SP389 →	+1.484	+5.031	<.001	.009	3	1
UCEC	RNU6-545P →	+0.663	+5.242	.001	.007	3	1
UCEC	RNA5SP326 →	+0.816	+5.771	.002	.003	3	1
UCEC	RNU6-271P →	+0.881	+5.852	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

LARP7P1 by C12orf75 expression — UCEC

Explore this box plot interactively →