C12orf75

Across TCGA pan-cancer cohorts, C12orf75 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C12orf75 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher C12orf75 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C12orf75 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

UVM, LIHC, and BLCA are the cancer types where C12orf75 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.390	0.768	<.001	124	view →
LIHC	OS	Median	All	0.692	0.861	<.001	52	view →
BLCA	DFS	Median	II,III,IV	0.558	0.671	.003	46	view →
LGG	OS	Median	All	0.751	0.865	<.001	39	view →
MESO	OS	Median	IV	0.329	0.787	.009	21	view →
BRCA	OS	Tertile	IV	0.709	0.180	.004	14	view →
ESCA	OS	Median	All	0.647	1.000	.015	9	view →
ACC	DFS	Median	IV	0.148	0.541	.003	8	view →
SKCM	DFS	Median	IV	0.628	0.227	.039	6	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	6	view →
LUAD	OS	Median	III,IV	0.187	0.371	.026	6	view →
KICH	DFS	Tertile	II,III,IV	0.365	0.874	.035	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C12orf75–UVM (DFS)

Open the UVM breakdown →