C12orf75

Across TCGA pan-cancer cohorts, C12orf75 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C12orf75’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C12orf75 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C12orf75 is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where C12orf75 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf75 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.801	<.001	12	view →
KICH	Male	All	+1.375	<.001	9	view →
LIHC	Male	II,III,IV	+2.049	<.001	8	view →
KIRP	Male	All	+0.814	<.001	8	view →
STAD	All	II,III,IV	+2.063	<.001	7	view →
BLCA	Male	III,IV	+2.028	.001	7	view →
COAD	Male	All	+0.910	<.001	7	view →
LUSC	All	II,III,IV	+1.203	<.001	5	view →
CHOL	Female	All	+5.486	<.001	3	view →
UCEC	All	IV	−2.330	.015	2	view →
PRAD	All	All	−1.472	<.001	2	view →
READ	All	All	+0.655	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C12orf75–HNSC

Open the HNSC breakdown →