C12orf40

Across TCGA patient cohorts, C12orf40 mutation is significantly associated with the RNA expression of many other genes, with 2,563 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf40-associated genes across cancer lineages are RNA5SP239, UQCRH, and TUBG1. Each is linked with C12orf40 in more than 2 cancer types. Because this analysis shows association rather than direction, both C12orf40-to-partner and partner-to-C12orf40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP239 grouped by C12orf40-low versus C12orf40-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf40→partner) and Y-score (partner→C12orf40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP239 →	+0.258	+4.277	<.001	.005	3	3
UCEC	UQCRH →	+0.636	+2.617	.006	<.001	3	3
UCEC	TUBG1 →	+0.524	+1.818	<.001	<.001	3	3
UCEC	POMP →	+0.306	+2.153	.006	<.001	3	3
UCEC	COX10 →	+0.320	+2.079	.001	.001	3	3
LUSC	RPSAP13 →	+0.154	+2.948	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,563 associations by consensus.

RNA5SP239 by C12orf40 expression — LUAD

Explore this box plot interactively →