C12orf40

Across TCGA pan-cancer cohorts, C12orf40 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of C12orf40’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C12orf40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C12orf40 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

KIRC, BRCA, and CHOL are the cancer types where C12orf40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.010	<.001	8	view →
BRCA	All	III,IV	−0.064	<.001	2	view →
CHOL	All	All	+0.008	.022	2	view →
KIRP	Male	All	+0.006	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

C12orf40–KIRC

Open the KIRC breakdown →