C12orf40

Across TCGA pan-cancer cohorts, C12orf40 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated C12orf40 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher C12orf40 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C12orf40 expression acts as an unfavorable survival marker, although some lineages such as COAD and BRCA show a favorable association.

KIRC, DLBC, and KICH are the cancer types where C12orf40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	IV	0.202	0.412	.005	43	view →
DLBC	OS	Tertile	All	0.468	1.000	.009	42	view →
KICH	DFS	Quartile	All	0.026	0.960	<.001	28	view →
CHOL	DFS	Tertile	All	0.091	0.446	.028	24	view →
COAD	OS	Quartile	III,IV	0.939	0.428	.008	22	view →
UCS	OS	Tertile	IV	0.253	0.691	.022	18	view →
BRCA	DFS	Median	III,IV	0.612	0.403	.007	18	view →
MESO	OS	Tertile	IV	0.188	0.622	.021	18	view →
LIHC	OS	Tertile	II,III,IV	0.878	0.530	.007	15	view →
LUSC	DFS	Quartile	All	0.278	0.530	.036	14	view →
ACC	OS	Quartile	III,IV	0.355	0.862	.017	10	view →
THYM	DFS	Quartile	II,III,IV	0.391	0.870	.022	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

C12orf40–KIRC (DFS)

Open the KIRC breakdown →