BUB1B

Across TCGA patient cohorts, BUB1B mutation is significantly associated with the RNA expression of many other genes, with 3,100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BUB1B-associated genes across cancer lineages are RN7SL280P, CCND2P1, and MIR3661. Each is linked with BUB1B in more than 2 cancer types. Because this analysis shows association rather than direction, both BUB1B-to-partner and partner-to-BUB1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL280P grouped by BUB1B-low versus BUB1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB1B→partner) and Y-score (partner→BUB1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL280P →	+0.327	+1.840	<.001	.001	3	3
COAD	CCND2P1 →	+0.268	+4.515	<.001	.002	3	3
UCEC	MIR3661 →	+0.520	+1.479	<.001	.006	3	3
SKCM	PSMD3 →	+0.448	+3.491	.002	.002	3	2
SKCM	SLC2A1 →	+1.061	+3.465	.002	.003	3	2
SKCM	CEP250 →	+0.521	+3.246	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,100 associations by consensus.

RN7SL280P by BUB1B expression — UCEC

Explore this box plot interactively →