BUB1B

Across TCGA pan-cancer cohorts, BUB1B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of BUB1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BUB1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BUB1B is over-expressed in tumor.

HNSC, LUAD, and BLCA are the cancer types where BUB1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BUB1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.915	<.001	12	view →
LUAD	Male	III,IV	+3.306	<.001	11	view →
BLCA	Male	III,IV	+3.154	<.001	11	view →
KIRP	All	III,IV	+1.722	<.001	11	view →
KIRC	Male	IV	+0.984	<.001	11	view →
COAD	Female	II,III,IV	+1.366	<.001	10	view →
LUSC	Female	II,III,IV	+3.682	<.001	9	view →
STAD	Female	All	+2.578	<.001	9	view →
LIHC	Female	II,III,IV	+1.755	<.001	9	view →
UCEC	All	II,III,IV	+3.637	<.001	8	view →
THCA	Female	III,IV	+0.984	<.001	8	view →
BRCA	All	III,IV	+2.477	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

BUB1B–HNSC

Open the HNSC breakdown →