BUB1B

Across TCGA pan-cancer cohorts, BUB1B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BUB1B data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher BUB1B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BUB1B expression acts as an unfavorable survival marker, although some lineages such as GBM and THYM show a favorable association.

KIRP, ACC, and MESO are the cancer types where BUB1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.771	0.929	<.001	144	view →
ACC	DFS	Median	All	0.335	0.821	<.001	133	view →
MESO	OS	Median	All	0.390	0.689	<.001	111	view →
LIHC	DFS	Median	All	0.452	0.630	<.001	98	view →
KICH	OS	Tertile	III,IV	0.253	0.942	.001	88	view →
UVM	DFS	Quartile	III,IV	0.274	0.922	<.001	86	view →
KIRC	DFS	Tertile	All	0.495	0.666	<.001	79	view →
LUAD	OS	Median	All	0.607	0.761	<.001	66	view →
BLCA	OS	Median	II,III,IV	0.653	0.781	.001	63	view →
LGG	OS	Median	All	0.726	0.900	<.001	53	view →
PAAD	OS	Median	All	0.284	0.510	.001	49	view →
SARC	OS	Median	All	0.398	0.624	<.001	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BUB1B–KIRP (DFS)

Open the KIRP breakdown →