BNIP3L

Across TCGA cell cohorts, BNIP3L mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BNIP3L-associated genes across cancer lineages are MS4A4A, MSGN1, and TBC1D21. Each is linked with BNIP3L in more than 1 cancer types. Because this analysis shows association rather than direction, both BNIP3L-to-partner and partner-to-BNIP3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by BNIP3L-low versus BNIP3L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP3L→partner) and Y-score (partner→BNIP3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.219	+3.678	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	C12orf40 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.213	+4.155	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MS4A4A by BNIP3L expression — LARGE_INTESTINE

Explore this box plot interactively →